ACVR2B (ACE-031) Bio-Peptide





ACVR2B (ACE-031) 10mg/vial ***New

What is ACE 031?

Today, scientists are actively working on a new group of drugs – myostatin blockers. One of the most promising is ACE 031. The drug is able to provide complete blocking of signals passing through receptors of the appropriate type. Currently, ACE 031 research is ongoing, but the preliminary results look very promising. In addition to its high effectiveness, scientists have not been able to find any side effects that may indicate the safety of this myostatin blocker. In bodybuilding, ACE 031 is used to obtain high-quality mass. Myostatin is a protein compound that is produced in the body and limits the growth of muscle mass. Scientists have been studying this substance for a long time and concluded that by qualitatively blocking its effect on the body, a powerful increase in muscle tissue can be achieved. Although ACE 031 is a very effective drug, its effects on the body should not be considered final. So far, only those effects that have already been proven in scientific research can be indicated. It is quite possible that the drug is able to have a broader effect on the body. The developed ACE-031 bait receptor is a synthetic version of the transmembrane protein receptor ACVR2B (active receptor IIB). ACE-031 is considered a strong myostatin inhibitor, which prevents myostatin from binding and triggering its natural ACVR2B receptor and inhibits muscle growth (because it prevents myostatin from entering the muscles, which limits the signal increase). Thus, ACE-031 significantly helps in muscle development and maintenance. Thanks to this property and ability, ACE-031 can help patients with symptoms of neuromuscular disease (muscle weakness and deterioration). Myostatin (GDF-8) is a myostatin released by myocytes and belongs to the TGF family of proteins. Myostatin (GDF-8) acts on the very functioning of muscle cells, inhibiting the growth and differentiation of muscle cells. In humans, it is encoded by the MCST gene, and the MCT gene is located on the long (q) arm of chromosome 2 at position 32.2. Human myostatin, with a total molecular weight of 25.0 kDa, consists of two identical subunits, each composed of 109 amino acid residues.

What are the advantages of ACE 031?

Safety of use – when using ACE 031 in recommended doses, no serious side effects were observed. Adverse effects such as headaches, dizziness and local injection reactions do occur but are so rare that they cannot be taken into account.
Significant acceleration of weight gain – when using the drug in an amount of 1 microgram per kilogram of body weight, the subjects showed an increase in muscle mass by 5.2%.

Increased bone density – the above doses increased bone density in the body.

Fat burning properties – ACE 031 is able to effectively reduce leptin levels while increasing adiponectin levels.

It may help patients with symptoms of neuromuscular disease when it comes to treating Duchenne muscular dystrophy

Strong anabolic and anti-catabolic effects, preventing muscle loss

Reduction of excess fat tissue

Does the use of ACE 031 cause any side effects?

The following side effects have been observed in very rare cases in clinical trials:

• Pain or irritation at the injection site
• Nosebleed
• Bleeding gums
• Fever

However, most of these side effects completely disappeared after stopping treatment and using ACE-031. Lost in words: it turns out that not only muscles but also blood vessels grow quickly.

What is ACE-031 used for?

ACE-031 is being developed by Acceleroon Pharma for the treatment of Duchenne muscular dystrophy (DMD).

Is myostatin a hormone?

Myostatin is a spontaneous and parathrin produced by muscle cells that inhibits muscle differentiation and growth. A lack of myostatin promotes skeletal muscle growth, and blocking its action has been proposed to treat various muscle wasting disorders.

What happens with myostatin deficiency?

In this case, muscle hypertrophy is considered a rather rare genetic disorder that is characterized by an increase in the size of skeletal muscles and a simultaneous decrease in adipose tissue. Myostatin is a negative regulator of sacrum extension and differentiation.

How to use ACE 031?

Although higher doses of AC-031 are also being mentioned in ongoing clinical trials, it is rather (in our opinion) that a safer dose of no more than 100-200 mcg of AAS-031 in a single injection should be considered. First, you need to dilute the powder, and this process is practically no different from preparing other peptides. The treatment cycle lasts ten days and should not be extended. You may not find this information in the instructions, but you should keep it in mind. By extending the service life of ACE 031, better results can be achieved. However, do not forget about possible side effects, the risk of which will increase. After a 10-day cycle, you should stop taking the peptide for another 10 days. Only then can the course be repeated. Acceptable doses of a myostatin blocker are in the range of 1-3 micrograms per kilogram of body weight. ACE 031 is only introduced once a day. This should be done in the morning or evening. On average, with a 10-day course of the drug, athletes gain about five kilograms of high-quality muscle mass.

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