Ibutamoren (MK 677) REWIX Labs




Usage: SARMS

Ibutamoren (MK 677) 25mg x 100tb

MK 677

MK-677 was originally developed for the treatment of muscle atrophy, obesity and osteoporosis, as well as for the recovery of elderly people with hip fractures. The main effects of this compound are determined by the increase in the production of growth hormone, which promotes rapid tissue repair, the growth of new cells, etc. In parallel with the increase in GH levels, the level of IGF-1 increases, which ensures stronger anabolism and energy storage. Effect of taking Mk677


MK-677 is a non-peptide agent very often classified as a SARM, but it does not belong to the SARM family. MK-677 is a ghrelin mimetic and belongs to the group of drugs that stimulate the production of growth hormone and IGF-1 (like peptides from the GHRP family , which is why it is very often used as an excellent replacement for growth hormone. The agent can be used for both therapeutic and regenerative purposes, as well as with the aim of building muscle mass. In the USA, MK677 has been approved by the FDA as a drug. As a ghrelin mimetic, it significantly stimulates appetite.


• Building lean muscle mass
• Losing fat tissue
• Improving sleep quality
• Improving skin quality (anti-aging effect)
• Increasing appetite
• Regeneration
• Regeneration of joints and tendons
• Healing of micro-injuries
• Does not affect the hormonal profile, does not block the pituitary axis -testes
• Favorable safety profile


The initial dose is 5-10 mg, the dose can be increased to 25 mg/day.
25mg is considered the optimal effective dose.
The maximum daily dose is 50mg – it can be divided into 2-3 portions, but this is not obligatory due to the 24-hour half-life. After administration, the maximum concentration is reached after 4-6 hours, therefore it is optimal for one of the doses to be taken before training.
MK-677 can be safely used for at least several months, provided that side effects are monitored. The agent can be combined with CJC and hormones.


• water retention
• increased appetite – may persist for up to 3 months after discontinuing the drug
• carbohydrate metabolism disorders (insulin resistance, diabetes) – with long-term use
• possible increase in cotisol and/or prolactin levels
• enlargement of organs with long-term use without periods of breaks
• neoplastic processes resulting from from multi-month cycles
• side effects typical of growth hormone


MK-677 Ibutamoren is an oral anabolic-anti-catabolic product based on (R)-1′-(2-methylalanyl-O-Benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4 ‘-piperidine], a chemical compound commonly known as Ibutamoren or MK-677. It imitates ghrelin, the action of which allows to increase the concentration of growth hormone (GH, somatotropin) and insulin-like growth factor 1 (IGF-1) and reduce the level of cortisol in the body. Ibutamoren, by affecting growth hormone receptors (GHS-R), allows you to increase the concentrations of: GH, IGF-1 and insulin-like growth factor-3 binding protein (IGFBP-3), which is necessary for its proper functioning. The ability to activate GHS-R has so far been attributed only to ghrelin. The mimicking of ghrelin in this area allowed the substance to be classified as a ghrelin mimetic. An appropriately high level of growth hormone is responsible for a number of important processes taking place in the body, including: development of the body, management of energy substrates, the degree of intensity of anabolic and catabolic changes, immune response and the functioning of the central nervous system. Regulating the secretion of somatotropin is the role of somatoliberin, somatostatin and IGF-1, and among the stimuli increasing its secretion the most frequently mentioned are: physical exercise, sleep, supply of appropriate amino acids, hunger and the accompanying ghrelin, and the availability of some other hormones. The release of GH leads to the increased binding of amino acids by muscle tissues, the synthesis and renewal of muscle fibers, the strengthening of the skeletal structure and the elimination of fat tissue.

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